Design and synthesis of 3-[(7-chloro-1-oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents
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چکیده
منابع مشابه
Synthesis and Antimicrobial Activity of 1-Thiazolidin-4-ones
A new series of 2-(3-oxo-3-phenylpropanoyl)-3-(substituted aryl)-1-thiazolidin-4-ones has been synthesized by cyclocondensation of ketoanils (the condensation products of 2, 4-dioxo-4phenyl butanal with primary amines) with mercaptoacetic acid. The chemical structures of the synthesized compounds were elucidated by elemental analysis, molecular weight determination, and UV, IR, 1H, 13C and DEPT...
متن کاملDesign and Synthesis of 4-flurophthalimides as potential anticonvulsant agents
Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...
متن کاملDesign and Synthesis of 4-flurophthalimides as potential anticonvulsant agents
Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...
متن کاملSynthesis and Pharmacological Investigation of Novel 2-(3-hydroxy-4-methoxy Phenyl)- 3-substituted-thiazolidin-4-ones as Anticonvulsants
A new series of 2,3-disubstituted thiazolidin-4-ones were obtained by the condensation of appropriate amines with vanillin and mercapto acetic acid in the presence of DCC in anhydrous THF by microwave irradiation. The title compounds were investigated for their anticonvulsant activity. Among the test compounds, compound N-(2-(3hydroxy-4-methoxyphenyl)-4-oxo thiazolidin-3-yl) isonicotinamide (3)...
متن کاملDesign and synthesis of some thiazolidin-4-ones based on (7-hydroxy-2-oxo-2H-chromen-4-yl) acetic acid.
(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid methyl ester(1) upon reaction with ethyl bromoacetate furnishes (7-ethoxycarbonylmethoxy-2-oxo-2H-chromen-4-yl)-acetic acid methylester (2), which on treatment with 100% hydrazine hydrate yields (7-hydrazinocarbonylmethoxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (3). The condensation of compound 3 with different aromatic aldehydes afforded a se...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2012
ISSN: 1475-6366,1475-6374
DOI: 10.3109/14756366.2012.710848